Promoting Autoimmune Diabetes in Non-Human Primates PRINCIPAL INVESTIGATOR:
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Award Number: W81XWH-11-1-0387 TITLE: Viral Oncolytic Therapeutics for Neoplastic Meningitis PRINCIPAL INVESTIGATOR: Mikhail Papisov, PhD CONTRACTING ORGANIZATION: Massachusetts General Hospital
s: 7. Papisov M, Belov V, Fischman A, Titus J, Gillooly C, Gagne M. PET imaging of macromolecule and particle delivery to the brain through intrathecal administration in rodents and non-human primates. 2012 SNM Annual Meeting, Miami, Fl.
متن کاملAward Number : W 81 XWH - 07 - 1 - 0121 TITLE : Humanized in vivo Model for Autoimmune Diabetes PRINCIPAL INVESTIGATOR
A human T-cell receptor (TcR) derived from an autoreactive T-cell specific for GAD65, from a subject at high risk for autoimmune diabetes, was introduced into HLA-DR4 transgenic mice. The source of TcR was a CD4þ TH1 þ T-cell clone which responded to an immunodominant epitope of the human islet protein GAD65, an epitope shared with both GAD65 and GAD67 in the mouse. The resulting HLA-DR4/GAD-Tc...
متن کاملAward Number : W 81 XWH - 07 - 1 - 0619 TITLE : Genetic and Environmental Pathways in Type 1 Diabetes Complications PRINCIPAL INVESTIGATOR : Massimo Trucco , M . D . CONTRACTING
s None
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متن کاملWhy does multiple sclerosis only affect human primates?
BACKGROUND Multiple sclerosis (MS) develops exclusively in humans. Non-human primates are resistant against MS, although they are highly susceptible to the MS animal model, experimental autoimmune encephalomyelitis (EAE). Unravelling of the cause(s) underlying this discrepancy is highly relevant as insights might be gained into the elusive event(s) that trigger(s) MS. A well-established differe...
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